Search Result

Results for "

ML 2-23

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) Arginase (1) Aurora Kinase (1) Autophagy (2) Bacterial (1) Bcr-Abl (1) Btk (3) c-Kit (1) CDK (2) COX (2) Cytochrome P450 (1) Dopamine Receptor (2) EGFR (1) Endogenous Metabolite (3) FAAH (2) Glucosidase (1) Histone Demethylase (1) HIV (1) JAK (1) MicroRNA (16) Monoamine Oxidase (2) mTOR (1) NEDD8-activating Enzyme (2) PERK (1) Phosphatase (1) PI3K (1) PROTACs (2) RAR/RXR (1) Reactive Oxygen Species (1) RXFP Receptor (1) Virus Protease (1)
By Research Areas:	Cancer (23) Cardiovascular Disease (1) Infection (3) Inflammation/Immunology (8) Metabolic Disease (1) Neurological Disease (2)

By Targets:

Apoptosis (3)

Arginase (1)

Aurora Kinase (1)

Autophagy (2)

Bacterial (1)

Bcr-Abl (1)

Btk (3)

c-Kit (1)

CDK (2)

COX (2)

Cytochrome P450 (1)

Dopamine Receptor (2)

EGFR (1)

Endogenous Metabolite (3)

FAAH (2)

Glucosidase (1)

Histone Demethylase (1)

HIV (1)

JAK (1)

MicroRNA (16)

Monoamine Oxidase (2)

mTOR (1)

NEDD8-activating Enzyme (2)

PERK (1)

Phosphatase (1)

PI3K (1)

PROTACs (2)

RAR/RXR (1)

Reactive Oxygen Species (1)

RXFP Receptor (1)

Virus Protease (1)

By Research Areas:

Cancer (23)

Cardiovascular Disease (1)

Infection (3)

Inflammation/Immunology (8)

Metabolic Disease (1)

Neurological Disease (2)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Arp2/3 Complex

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-139398

TBI-223 1 Publications Verification	Bacterial	Infection
TBI-223 is an orally bioavailable oxazolidinone antibiotic and an antimicrobial. TBI-223 shows activity against Mycobacterium tuberculosis (Mtb) .

HY-16956

Onatasertib 2 Publications Verification CC-223; ATG-008	mTOR Apoptosis	Cancer
Onatasertib (CC-223) is a potent, selective, and orally bioavailable inhibitor of mTOR kinase, with an IC₅₀ value for mTOR kinase of 16 nM. Onatasertib inhibits both mTORC1 and mTORC2.

HY-132231

FD223	PI3K Apoptosis	Cancer
FD223 is a potent and selective phosphoinositide 3-kinase delta (PI3Kδ) inhibitor. FD223 displays high potency (IC₅₀=1 nM) and good selectivity over other isoforms (IC₅₀s of 51 nM, 29 nM and 37 nM, respectively for α, β and γ). FD223 exhibits efficient inhibition of the proliferation of acute myeloid leukemia (AML) cell lines by suppressing p-AKT Ser473 thus causing G1 phase arrest during the cell cycle. FD223 has potential for the research of leukemia such as AML .

HY-153582

ML 2-23

PROTACs Bcr-Abl Cancer

ML 2-23 is a potent PROTAC BCR-ABL degrader. ML 2-23 is selectively degrade BCR-ABL in a proteasome-dependent manner in leukemia cells .

ML 2-23	PROTACs Bcr-Abl	Cancer
ML 2-23 is a potent PROTAC BCR-ABL degrader. ML 2-23 is selectively degrade BCR-ABL in a proteasome-dependent manner in leukemia cells .

HY-144742

NS2B/NS3-IN-6	Virus Protease	Infection
NS2B/NS3-IN-6 (Compound 1a) is an allosteric DENV and ZIKV NS2B/NS3 protease inhibitor with IC₅₀ values of 2.23 µM and 25.2 µM against ZIKV and DENV proteases, respectively .

HY-123772

CDK5 inhibitor 20-223	CDK	Cancer
CDK5 inhibitor 20-223 is a potent CDK2 and CDK5 inhibitor with IC₅₀s of 6.0 and 8.8 nM, respectively. CDK5 inhibitor 20-223 is an effective anti-colorectal cancer (CRC) agent .

HY-101790

ZM223

NEDD8-activating Enzyme Cancer

ZM223 is a potent non-covalent NEDD8 activating enzyme (NAE) inhibitor, orally active .

ZM223	NEDD8-activating Enzyme	Cancer
ZM223 is a potent non-covalent NEDD8 activating enzyme (NAE) inhibitor, orally active .

HY-76574

3-(Trifluoromethyl)benzaldehyde	Others	Cancer
3-(Trifluoromethyl)benzaldehyde is an active compound, and can be used for the synthesis of 2,3-di- and 2,2,3-trisubstituted-3-methoxycarbonyl-γ-butyrolactones. 2,3-di- and 2,2,3-trisubstituted-3-methoxycarbonyl-γ-butyrolactones are potent antitumor agents .

HY-15775

Arginase inhibitor 1

4 Publications Verification

Arginase Cancer

Arginase inhibitor 1 is a potent inhibitor of human arginases I and II with IC₅₀s of 223 and 509 nM, respectively.
HY-N12284

6-Methoxy-2-[2-(3′-methoxyphenyl)ethyl]chromone

Others Others

6-Methoxy-2-[2-(3′-methoxyphenyl)ethyl]chromone (compound 12) is a chromenone .

Arginase inhibitor 1 4 Publications Verification	Arginase	Cancer
Arginase inhibitor 1 is a potent inhibitor of human arginases I and II with IC₅₀s of 223 and 509 nM, respectively.

6-Methoxy-2-[2-(3′-methoxyphenyl)ethyl]chromone	Others	Others
6-Methoxy-2-[2-(3′-methoxyphenyl)ethyl]chromone (compound 12) is a chromenone .

HY-101790A

ZM223 hydrochloride	NEDD8-activating Enzyme	Cancer
ZM223 hydrochloride is an orally active, potent non-covalent NEDD8 activating enzyme (NAE) inhibitor with excellent anticancer activity .

HY-112802

AZD3229

c-Kit Cancer

AZD3229 is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors. AZD3229 inhibits c-KIT with an IC₅₀ value of 223.3 nM .

AZD3229	c-Kit	Cancer
AZD3229 is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors. AZD3229 inhibits c-KIT with an IC₅₀ value of 223.3 nM .

HY-N3737

Derrone	Aurora Kinase PERK Reactive Oxygen Species	Cancer
Derrone, a prenylated isoflavones, is an Aurora kinase inhibitor, with IC₅₀ values of 6 and 22.3 μM against Aurora B and Aurora A, respectively. Derrone shows anti-tumor activity .

HY-R00467

*hsa-miR-223-3p mimic*	MicroRNA	Cancer
hsa-miR-223-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-223-3p mimic hsa-miR-223-3p mimic

HY-R00468

*hsa-miR-223-5p mimic*	MicroRNA	Cancer
hsa-miR-223-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-223-5p mimic hsa-miR-223-5p mimic

HY-R02848

*mmu-miR-223-5p mimic*	MicroRNA	Cancer
mmu-miR-223-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-miR-223-5p mimic mmu-miR-223-5p mimic

HY-R04313

*rno-miR-223-3p mimic*	MicroRNA	Cancer
rno-miR-223-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

rno-miR-223-3p mimic rno-miR-223-3p mimic

HY-101521

CHMFL-BTK-01	Btk	Cancer
CHMFL-BTK-01 (compound 9) is a highly selective irreversible BTK inhibitor, with an IC₅₀ of 7 nM. CHMFL-BTK-01 (compound 9) potently inhibited BTK Y223 auto-phosphorylation .

HY-119518

BMS641 BMS-209641	RAR/RXR	Cancer
BMS641 (BMS-209641) is a selective RARβ agonist. BMS641 has a higher affinity for RARβ (K_d, 2.5 nM) that is 100 times higher than that for RARα (K_d, 225 nM) or RARγ (K_d, 223 nM) .

HY-B1227

Carprofen 2 Publications Verification
Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC₅₀s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.

HY-132914

CDK/HDAC-IN-1

CDK Cancer

CDK/HDAC-IN-1 shows remarkable CDK2/4/6 and HDAC6 inhibitory activity of IC₅₀ = 60.9 ± 2.9, 276 ± 22.3, 27.2 ± 4.2, and 128.6 ± 0.4 nM, respectively.

CDK/HDAC-IN-1	CDK	Cancer
CDK/HDAC-IN-1 shows remarkable CDK2/4/6 and HDAC6 inhibitory activity of IC₅₀ = 60.9 ± 2.9, 276 ± 22.3, 27.2 ± 4.2, and 128.6 ± 0.4 nM, respectively.

HY-156538

RXFP1 receptor agonist-3	RXFP Receptor	Inflammation/Immunology
RXFP1 receptor agonist-3 (Example 223) is a RXFP1 receptor agonist. RXFP1 receptor agonist-3 inhibits cAMP production in HEK293 cells stably expressing human RXFP1, with an EC₅₀ value of 2 nM .

HY-162257

BTK-IN-34	Btk	Cancer
BTK-IN-34 (compound 9h) is a selective BTK inhibitor. BTK-IN-34 shows antiproliferative activity in RAMOS cells through selective inhibition of pBTK (Tyr223) without affecting Lyn and Syk, upstream proteins in the BCR signaling pathway .

HY-B1227S

Carprofen-d3	COX FAAH Autophagy Endogenous Metabolite	Inflammation/Immunology
Carprofen-d₃ is the deuterium labeled Carprofen. Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.

HY-151920

BTK-IN-17	Btk	Inflammation/Immunology
BTK-IN-17 (compound 36R) is a selective and orally activeBTK inhibitor with an IC₅₀ value of 13.7 nM. BTK-IN-17 decreases the expression of p-BTK ^Y223 and p-PLCγ2 ^Y1217. BTK-IN-17 shows anti-inflammatory effects .

HY-123921

Gefitinib-based PROTAC 3 1 Publications Verification	PROTACs EGFR	Cancer
Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a von Hippel-Lindau ligand via a linker, induces EGFR degradation with DC₅₀s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively .

HY-RI00467

*hsa-miR-223-3p inhibitor*	MicroRNA
hsa-miR-223-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-223-3p inhibitor hsa-miR-223-3p inhibitor

HY-RI00468

*hsa-miR-223-5p inhibitor*	MicroRNA
hsa-miR-223-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-223-5p inhibitor hsa-miR-223-5p inhibitor

HY-RI02848

*mmu-miR-223-5p inhibitor*	MicroRNA
mmu-miR-223-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-miR-223-5p inhibitor mmu-miR-223-5p inhibitor

HY-RI04313

*rno-miR-223-3p inhibitor*	MicroRNA
rno-miR-223-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

rno-miR-223-3p inhibitor rno-miR-223-3p inhibitor

HY-B1227S1

Carprofen-13C,d3	FAAH COX Autophagy Endogenous Metabolite	Inflammation/Immunology
Carprofen- ¹³C,d₃ is the deuterium and ¹³C labeled Carprofen[1]. Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively[2][3][4].

HY-145352

ChemR23-IN-2

Others Inflammation/Immunology

ChemR23-IN-2 is a potent and orally efficacious ChemR23 inhibitor with an IC₅₀ value of 3.2 nM.

ChemR23-IN-2	Others	Inflammation/Immunology
ChemR23-IN-2 is a potent and orally efficacious ChemR23 inhibitor with an IC₅₀ value of 3.2 nM.

HY-12697A

NGB 2904 hydrochloride	Dopamine Receptor	Neurological Disease
NGB 2904 hydrochloride is a potent, selective, orally active and brain-penetrated antagonist of dopamine D3 receptor, with a K_i of 1.4 nM. NGB 2904 hydrochloride shows selectivity for D3 over D2, 5-HT2, α1, D4, D1 and D5 receptors (K_is=217, 223, 642, >5000, >10000 and >10000 nM, respectively). NGB 2904 hydrochloride antagonizes Quinpirole-stimulated mitogenesis .

HY-12697

NGB 2904	Dopamine Receptor	Neurological Disease
NGB 2904 is a potent, selective, orally active and brain-penetrated antagonist of dopamine D3 receptor, with a K_i of 1.4 nM. NGB 2904 shows selectivity for D3 over D2, 5-HT2, α1, D4, D1 and D5 receptors (K_is=217, 223, 642, >5000, >10000 and >10000 nM, respectively). NGB 2904 antagonizes Quinpirole-stimulated mitogenesis .

HY-R00467A

*hsa-miR-223-3p agomir*	MicroRNA
hsa-miR-223-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-223-3p agomir hsa-miR-223-3p agomir

HY-R00468A

*hsa-miR-223-5p agomir*	MicroRNA
hsa-miR-223-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-223-5p agomir hsa-miR-223-5p agomir

HY-R02848A

*mmu-miR-223-5p agomir*	MicroRNA
mmu-miR-223-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-223-5p agomir mmu-miR-223-5p agomir

HY-R04313A

*rno-miR-223-3p agomir*	MicroRNA
rno-miR-223-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

rno-miR-223-3p agomir rno-miR-223-3p agomir

HY-134664

8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate	Cytochrome P450 Monoamine Oxidase	Inflammation/Immunology
8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate is an irreversible CYP2A6 inhibitor with IC₅₀s of 8.64 μM and 22.3 μM with pre-incubation and co-incubaition, respectively. 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate also inhibits MAO-A and MAO-B with IC₅₀s of 60.2 and 38.6 μM, respectively .

HY-156287

GCase modulator-1

Glucosidase Cancer

GCase modulator-1 (compound 9g), a derivative of Quinazoline, is a modulator of GCase (Glucosidase) (AC₅₀=2.23 μM) .

GCase modulator-1	Glucosidase	Cancer
GCase modulator-1 (compound 9g), a derivative of Quinazoline, is a modulator of GCase (Glucosidase) (AC₅₀=2.23 μM) .

HY-N11939

Kadsuralignan A	HIV	Infection
Kadsuralignan A (compound 1) is a dibenzocyclooctadiene lignan isolated from the leaves and stems of Schisandra lancifolia. Kadsuralignan A has anti-HIV activity with *EC₅₀*=2.23 μg/mL .

HY-RI00467A

*hsa-miR-223-3p antagomir*	MicroRNA
hsa-miR-223-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-223-3p antagomir hsa-miR-223-3p antagomir

HY-RI00468A

*hsa-miR-223-5p antagomir*	MicroRNA
hsa-miR-223-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-223-5p antagomir hsa-miR-223-5p antagomir

HY-RI02848A

*mmu-miR-223-5p antagomir*	MicroRNA
mmu-miR-223-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-223-5p antagomir mmu-miR-223-5p antagomir

HY-RI04313A

*rno-miR-223-3p antagomir*	MicroRNA
rno-miR-223-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

rno-miR-223-3p antagomir rno-miR-223-3p antagomir

HY-N3057

Pinostrobin chalcone	Others	Cancer
Pinostrobin chalcone is found to be potent natural cytotoxic compounds against MDA-MB-231 and HT-29 colon cancer cell lines(IC₅₀ = 20.42±2.23 and 22.51±0.42 μg/mL) .

HY-144673

LSD1-IN-12	Histone Demethylase Monoamine Oxidase	Cancer
LSD1-IN-12 (compound 2) is a potent LSD1 inhibitor, with K_i values of 1.1 μM (LSD1), 61 μM (LSD2), 2.3 μM (MAO-A), and 3.5 μM (MAO-B), respectively .

HY-108342

PF-00956980	JAK	Inflammation/Immunology
PF-00956980 is a reversible pan-JAK inhibitor with IC₅₀ values of 2.2, 23.1 and 59.9 μM for JAK1, JAK2 and JAK3, respectively. PF-00956980 can be used in the research of lung and skin inflammatory diseases .

HY-128853S

Taurodeoxycholate-d6 sodium salt	Endogenous Metabolite	Inflammation/Immunology
Taurodeoxycholate-d₆ (sodium salt) is the deuterium labeled Taurodeoxycholate sodium salt[1]. Taurodeoxycholate sodium salt is a bile salt-related anionic detergent used for isolation of membrane proteins including inner mitochondrial membrane proteins. Taurodeoxycholate (TDCA) inhibits various inflammatory responses[2]. [2][3].

HY-126923

2,3-Dinor thromboxane B2 2,3-Dinor-TXB2	Others	Cardiovascular Disease Metabolic Disease
2,3-Dinor thromboxane B2 (2,3-Dinor-TXB2), a metabolite of urine, serves as an indicator of the production of thromboxane A2 (TxA2) in the body, and can be used as a tool to study the role of thromboxane in various pathophysiological processes in the human body .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3057

Pinostrobin chalcone	Flavonoids Chalcones Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Plants Disease Research Fields Cancer Cajanus cajan (L.) Millsp.	Others
Pinostrobin chalcone is found to be potent natural cytotoxic compounds against MDA-MB-231 and HT-29 colon cancer cell lines(IC₅₀ = 20.42±2.23 and 22.51±0.42 μg/mL) .

HY-N12284

6-Methoxy-2-[2-(3′-methoxyphenyl)ethyl]chromone	Structural Classification Natural Products Thymelaeaceae Source classification Aquilaria malaccensis Lam. Plants	Others
6-Methoxy-2-[2-(3′-methoxyphenyl)ethyl]chromone (compound 12) is a chromenone .